The diagnosis of various oral lesions by taking tissue samples (biopsy) from patients and preparing slides and observing them under microscopes is done here. This department is the back bone of the many other departments of this college. Specimens from all the department are analyzed here. most advanced diagnostic equipments are installed here. Department fulfills its social obligation by doing investigation at subsidized rates. Department have state of art services including standard tissue processing & staining, immunofluorescence, flow cytometry & immunocytochemistry.

The department has 3 post graduate seats & duration of training is 3 years. Post graduates are trained in hematology, histopathology, biochemical analysis & clinical Evaluations.

Department is headed by Prof Vineet Raj. Who did his MDS from Manipal in 2006. He is having experience of 11 years.